Back to Home

Predictive Power

Below, we present the prediction performance on an 'out-of-sample' test set of European ancestry first-degree relatives in the UK Biobank. These individuals were excluded from model development, allowing us to assess the true relationship between our genetic predictors and phenotypes.

Sibling pairs offer a unique way to evaluate how well our predictors capture direct biological effects. We demonstrate the ability to identify, from DNA alone, which sibling expresses a specific trait or has a higher value for a continuous phenotype (e.g., greater height).